Science
Senda is harnessing millions of years of evolution to pioneer fully programmable medicines.
Realizing the full potential of the information molecule era
Following a lengthy period of drug development driven more by trial and error than precision targeting, recent advances in our understanding of the genetic code—a natural programming language—have ushered in the age of rationally designed information molecules.
We can now program various information molecules —mRNA, DNA, siRNA, gene editors, and more—but have yet to fully deliver on the enormous potential of programmable medicines. There is a critical missing link: the ability to get these information molecules to cells of interest in the body.
Programming to the cell using the code from natural nanoparticles
Senda is founded on the insight that human and non-human cells coevolved to exchange molecules continually. Natural nanoparticles evolved to shuttle information biomolecules into human cells, displaying tropism, potency, and repeatability in their interactions.
Senda is the first company to decode this natural programming language to unlock full programming to the cell.
Fig 1. Universe Within
Within the human ecosystem, coevolved non-human cells continually exchange molecules with our own cells. This intricate exchange—facilitated by natural nanoparticles that precisely shuttle biomolecules into human cells—provides the missing pieces to fully unlock programmable medicines.
Fig 2. Molecular Diversity: Natural vs. Synthetic nanoparticles
Natural nanoparticles offer significantly more structural and chemical diversity than the synthetic nanoparticles widely used today, providing a much larger programming toolkit.
Source: Senda Atlas, accessing the code from nature vs. industry state-of-the-art-LNP
More diverse targeting options than existing methods
There is an expansive multitude of natural nanoparticles carrying unique chemical addresses. Senda is deconstructing these addresses and mapping them in a vast proprietary catalog derived from natural nanoparticles extracted from species across 4 kingdoms of life.
Harnessing nature’s complete code to make more effective therapeutics
Senda deconstructs the components of these particles into a chemical code that forms the basis of our nanoparticle programming language.
Using the subcomponents, we are programming a wide range of therapeutically desirable bioproperties, such as cell tropism and repeatable dosing, via previously inaccessible routes of administration.
Fig 3. Potent targeting to diverse cells and tissues
Natural nanoparticles: Co-evolved over millions of years to send molecules to human cells